γδ T Cell Therapy Development for Prostate Cancer

Gamma-delta (γδ) T cells are a distinct subgroup of T cells which contain T cell receptors (TCRs) γ and δ chains rather than conventional α and β chains, therefore, they present unique features related to antigen recognition capacity, tissue tropism, and cytotoxic function. As a bridge between the innate and adaptive immune systems, γδ T cells hold promise for cancer immunotherapy, including prostate cancer. As a leader in the research of γδ T cells and cancer immunotherapy, Creative Biolabs is driven to provide comprehensive γδ T cells development and engineering services. Our scientific support helps global customers develop a portfolio of γδ T cells & antibodies & proteins against prostate cancer.

Antitumour Functions of γδ T Cells

Although γδ T cells constitute a minor subset (1-5%) of total circulating T cells, they possess a combination of innate and adaptive immune cell qualities. In immunotherapy, γδ T cells exert direct/indirect antitumor cytotoxicity, produce inflammatory cytokines, directly lyse infected or malignant cells, and establish a memory response to attack pathogens upon re-exposure.

Fig.1 Antitumour γδ T cell functions and their regulation. (Silva-Santos, 2019)

• Direct tumor cell targeting by γδ T cells

γδ T cells play a direct antitumor role mainly from four different aspects: (1) directly lyse cancer cells through the perforin-granzyme pathway; (2) eliminate cancer cells through the ligands TRAIL and FasL that can enhance the susceptibility of the cancer cells to γδ T cell lysis; (3) kill cancer cells via antibody-dependent cell-mediated cytotoxicity (ADCC); (4) γδ T cells are important early sources of IFN-γ and TNF-α to inhibit cancer growth.

• Indirect effects οf γδ T cells on antitumor immunity

γδ T cells exert their indirect antitumor effect by orchestrating downstream immune responses. They can interact with B cells, DCs, αβ T cells, and NK cells to participate in tumor immune regulation. For example, γδ T cells have been shown to affect B cell antibody secretion in non-immunized mice. In addition, they can also act as antigen presenting cells (APCs) for αβ T cell priming. DC maturation and robust NK cell-mediated antitumor cytotoxicity are also associated with γδ T cells.

γδ T Cells and Prostate Cancer

Prostate cancer is a common type of cancer in males that affects thousands of men each year. It has been the second-leading cause of cancer death for men in the United States. Protective effects by γδ T cells have been validated in models of B cell lymphoma, colorectal cancer and prostate cancer. Liu et al. (2008) used a transgenic mouse model of prostate cancer (TRAMP) to firstly reveal that γδ T cells can provide protective immunosurveillance against spontaneously arising mouse prostate cancer. TRAMP is a model of spontaneously arising mouse prostate cancer that mimics human disease. Therefore, these findings provide scientific evidence that γδ T cells provide protective innate immunosurveillance against prostate cancer, and they provide a rationale for designing adoptive transfer of ex vivo expanded autologous γδ T cells to treat prostate cancer.

Services at Creative Biolabs

With proven expertise in immunotherapy development, Creative Biolabs aspires to become a leading, fully integrated biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of γδ T cell immunotherapies. Our capacities have been well-recognized in γδ T cell receptors analysis (γδ TCR repertoires analysis, γδ TCR transcriptome analysis, etc.), γδ T cell development (isolation, activation and expansion, characterization, production, cytotoxicity test, etc.), and γδ T cell engineering services (CAR engineered-, αβ TCR-engineered γδ T cell development, bispecific γδ T cell antibody development, γδ T cell hybridomas development, etc.). We can provide flexible solutions for your choice, either stand-alone service or integrated project is both welcome to meet every specific demand.

Why Us?

• Top-rated customer experience
• High flexibility and cost-effectiveness
• Reliability and information security
• Deadline driven account management
• Tailored research & services

γδ T cells are being exploited increasingly for cancer immunotherapy. Based on our advanced technology and abundant experience, Creative Biolabs offers high-quality customized services covering the entire γδ T cell development process to best suit your technical, program, and budget requirements. If the above services do not meet your requirements, please contact us for your exclusive solution.

References

1. Silva-Santos, B.; et al. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer. 2019, 19(7): 392-404.
2. Liu, Z.; et al. Protective immunosurveillance and therapeutic antitumor activity of γδ T cells demonstrated in a mouse model of prostate cancer. The Journal of Immunology. 2008, 180(9): 6044-6053.