γδ T Cell Therapy Development for Prostate CancerOnline Inquiry
Gamma-delta (γδ) T cells are a distinct subgroup of T cells which contain T cell receptors (TCRs) γ and δ chains rather than conventional α and β chains, therefore, they present unique features related to antigen recognition capacity, tissue tropism, and cytotoxic function. As a bridge between the innate and adaptive immune systems, γδ T cells hold promise for cancer immunotherapy, including prostate cancer. As a leader in the research of γδ T cells and cancer immunotherapy, Creative Biolabs is driven to provide comprehensive γδ T cells development and engineering services. Our scientific support helps global customers develop a portfolio of γδ T cells & antibodies & proteins against prostate cancer.
Antitumour Functions of γδ T Cells
Although γδ T cells constitute a minor subset (1-5%) of total circulating T cells, they possess a combination of innate and adaptive immune cell qualities. In immunotherapy, γδ T cells exert direct/indirect antitumor cytotoxicity, produce inflammatory cytokines, directly lyse infected or malignant cells, and establish a memory response to attack pathogens upon re-exposure.
Fig.1 Antitumour γδ T cell functions and their regulation. (Silva-Santos, 2019)
- Direct tumor cell targeting by γδ T cells
- Indirect effects οf γδ T cells on antitumor immunity
γδ T cells play a direct antitumor role mainly from four different aspects: (1) directly lyse cancer cells through the perforin-granzyme pathway; (2) eliminate cancer cells through the ligands TRAIL and FasL that can enhance the susceptibility of the cancer cells to γδ T cell lysis; (3) kill cancer cells via antibody-dependent cell-mediated cytotoxicity (ADCC); (4) γδ T cells are important early sources of IFN-γ and TNF-α to inhibit cancer growth.
γδ T cells exert their indirect antitumor effect by orchestrating downstream immune responses. They can interact with B cells, DCs, αβ T cells, and NK cells to participate in tumor immune regulation. For example, γδ T cells have been shown to affect B cell antibody secretion in non-immunized mice. In addition, they can also act as antigen presenting cells (APCs) for αβ T cell priming. DC maturation and robust NK cell-mediated antitumor cytotoxicity are also associated with γδ T cells.
γδ T Cells and Prostate Cancer
Prostate cancer is a common type of cancer in males that affects thousands of men each year. It has been the second-leading cause of cancer death for men in the United States. Protective effects by γδ T cells have been validated in models of B cell lymphoma, colorectal cancer and prostate cancer. Liu et al. (2008) used a transgenic mouse model of prostate cancer (TRAMP) to firstly reveal that γδ T cells can provide protective immunosurveillance against spontaneously arising mouse prostate cancer. TRAMP is a model of spontaneously arising mouse prostate cancer that mimics human disease. Therefore, these findings provide scientific evidence that γδ T cells provide protective innate immunosurveillance against prostate cancer, and they provide a rationale for designing adoptive transfer of ex vivo expanded autologous γδ T cells to treat prostate cancer.
Services at Creative Biolabs
With proven expertise in immunotherapy development, Creative Biolabs aspires to become a leading, fully integrated biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of γδ T cell immunotherapies. Our capacities have been well-recognized in γδ T cell receptors analysis (γδ TCR repertoires analysis, γδ TCR transcriptome analysis, etc.), γδ T cell development (isolation, activation and expansion, characterization, production, cytotoxicity test, etc.), and γδ T cell engineering services (CAR engineered-, αβ TCR-engineered γδ T cell development, bispecific γδ T cell antibody development, γδ T cell hybridomas development, etc.). We can provide flexible solutions for your choice, either stand-alone service or integrated project is both welcome to meet every specific demand.
- Top-rated customer experience
- High flexibility and cost-effectiveness
- Reliability and information security
- Deadline driven account management
- Tailored research & services
γδ T cells are being exploited increasingly for cancer immunotherapy. Based on our advanced technology and abundant experience, Creative Biolabs offers high-quality customized services covering the entire γδ T cell development process to best suit your technical, program, and budget requirements. If the above services do not meet your requirements, please contact us for your exclusive solution.
- Silva-Santos, B.; et al. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer. 2019, 19(7): 392-404.
- Liu, Z.; et al. Protective immunosurveillance and therapeutic antitumor activity of γδ T cells demonstrated in a mouse model of prostate cancer. The Journal of Immunology. 2008, 180(9): 6044-6053.