γδ T Cell Therapy Development Services for Neurological DiseasesOnline Inquiry
γδ T cells are a distinct subgroup of T cells that play a pivotal role in many neurological diseases. They are suggested to be responsible for inducing or maintaining the proinflammatory environment characteristic of these diseases. With access to advanced instruments, fit-for-purpose laboratories, and professional knowledge, Creative Biolabs provides a full range of services to support our clients in developing γδ T cells and thus, to advance the basic research and clinical therapeutics of neurological diseases.
γδ T cells and Neurological Diseases
γδ T cells function as inflammatory cells to involve in many neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), encephalomyelitis and Rasmussen encephalitis (RE).
- γδ T cells & PD
- γδ T cells & AD
- γδ T cells & encephalomyelitis
- γδ T cells & RE
It has been documented that the proportions of γδ T cells were increased in the cerebrospinal fluid (CSF) and peripheral blood from PD patients, moreover, patients with PD usually had higher numbers of γδ T cells. These data suggested that γδ T cells may play in PD pathogenesis and also provided new insights into PD therapies.
AD is an incurable neurodegenerative disorder in which neuroinflammation has a critical function. The roles of γδ T cells in AD are gradually understood by deep sequencing of the CDR3 region of T-cell receptor γ genes (TRGs) in patients with AD and control patients. Scientists found that AD was associated with a unique TRG repertoire, and the chemical properties of CDR3 regions may be altered in AD. These findings highlighted the potential of AD-γδ TCR repertoires as new biomarkers for prediction and diagnosis of AD.
γδ T cells can be activated to induce various inflammatory cytokines, such as IFN-γ, IL-4, IL-17, IL-21, and IL-22. In encephalomyelitis cases, γδ T cells function as the major initial producers of IL-17, suggesting their crucial role in the pathogenesis of encephalomyelitis. Additionally, γδ T cells express high levels of IL-23R and IL-1R, which further enhance their effector functions in the pathogenesis of encephalomyelitis.
RE is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. It was often accompanied by clusters of T cells in the affected cortical hemisphere, indicating an active cellular immune response. Activated γδ T cells are associated with neuroinflammation in RE. In RE cases, the inflammatory factor IFN-γ is increased, which is the product of γδ T cells, suggesting γδ T cells can be considered as a marker of RE as well as the indicators of the choice of therapy for future practice.
Our Featured Services about γδ T Cells
With proven experience and expertise in γδ T cells research, Creative Biolabs provides a comprehensive range of customized, high-quality contract R&D services in γδ T cells development and engineering services to support the research of neurological diseases. We aim to accelerate industry development through our stand-alone service or executing projects in an integrated manner.
γδ T cells isolation, activation and expansion, characterization, production, cytotoxicity test, etc.γδ T Cell Development Services
TCR repertoires analysis, TCR transcriptome analysis, TCR Generation, and TCR-ligand reaction analysis, etc.γδ T Cell Receptors Services
CAR engineered-, αβ TCR-engineered γδ T cell development, bispecific γδ T cell antibody development, γδ T cell hybridomas development, etc.γδ T Cell Engineering Services
γδ T Cells
γδ T cells are involved in a number of neurological diseases which suggests that therapies directed toward γδ T cells with immunotherapeutic may have an important role in the treatment of these conditions. As a leader in the research of γδ T cells, Creative Biolabs is dedicated to providing one-stop γδ T cells development services to promote the basic research of neurological diseases. We can offer you the highest quality, accuracy and precision, and a fast turnaround to meet deadlines. If the above services do not meet your requirements, please contact us for your exclusive solution.