Therapy Development

γδ T Cell Therapy Development Services for Neurological Diseases

γδ T Cell Therapy Development Services for Neurological Diseases

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γδ T Cell Therapy Development Services for Neurological Diseases

γδ T cells are a distinct subgroup of T cells that play a pivotal role in many neurological diseases. They are suggested to be responsible for inducing or maintaining the proinflammatory environment characteristic of these diseases. With access to advanced instruments, fit-for-purpose laboratories, and professional knowledge, Creative Biolabs provides a full range of services to support our clients in developing γδ T cells and thus, to advance the basic research and clinical therapeutics of neurological diseases.

γδ T cells and Neurological Diseases

γδ T cells function as inflammatory cells to involve in many neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), encephalomyelitis and Rasmussen encephalitis (RE).

  • γδ T cells & PD
  • It has been documented that the proportions of γδ T cells were increased in the cerebrospinal fluid (CSF) and peripheral blood from PD patients, moreover, patients with PD usually had higher numbers of γδ T cells. These data suggested that γδ T cells may play in PD pathogenesis and also provided new insights into PD therapies.

  • γδ T cells & AD
  • AD is an incurable neurodegenerative disorder in which neuroinflammation has a critical function. The roles of γδ T cells in AD are gradually understood by deep sequencing of the CDR3 region of T-cell receptor γ genes (TRGs) in patients with AD and control patients. Scientists found that AD was associated with a unique TRG repertoire, and the chemical properties of CDR3 regions may be altered in AD. These findings highlighted the potential of AD-γδ TCR repertoires as new biomarkers for prediction and diagnosis of AD.

  • γδ T cells & encephalomyelitis
  • γδ T cells can be activated to induce various inflammatory cytokines, such as IFN-γ, IL-4, IL-17, IL-21, and IL-22. In encephalomyelitis cases, γδ T cells function as the major initial producers of IL-17, suggesting their crucial role in the pathogenesis of encephalomyelitis. Additionally, γδ T cells express high levels of IL-23R and IL-1R, which further enhance their effector functions in the pathogenesis of encephalomyelitis.

  • γδ T cells & RE
  • RE is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. It was often accompanied by clusters of T cells in the affected cortical hemisphere, indicating an active cellular immune response. Activated γδ T cells are associated with neuroinflammation in RE. In RE cases, the inflammatory factor IFN-γ is increased, which is the product of γδ T cells, suggesting γδ T cells can be considered as a marker of RE as well as the indicators of the choice of therapy for future practice.

Our Featured Services about γδ T Cells

With proven experience and expertise in γδ T cells research, Creative Biolabs provides a comprehensive range of customized, high-quality contract R&D services in γδ T cells development and engineering services to support the research of neurological diseases. We aim to accelerate industry development through our stand-alone service or executing projects in an integrated manner.

γδ T Cell Therapy Development Services for Neurological Diseases

γδ T cells isolation, activation and expansion, characterization, production, cytotoxicity test, etc.

γδ T Cell Development Services

TCR repertoires analysis, TCR transcriptome analysis, TCR Generation, and TCR-ligand reaction analysis, etc.

γδ T Cell Receptors Services

CAR engineered-, αβ TCR-engineered γδ T cell development, bispecific γδ T cell antibody development, γδ T cell hybridomas development, etc.

γδ T Cell Engineering Services

γδ T Cells

Neurological Diseases

γδ T cells are involved in a number of neurological diseases which suggests that therapies directed toward γδ T cells with immunotherapeutic may have an important role in the treatment of these conditions. As a leader in the research of γδ T cells, Creative Biolabs is dedicated to providing one-stop γδ T cells development services to promote the basic research of neurological diseases. We can offer you the highest quality, accuracy and precision, and a fast turnaround to meet deadlines. If the above services do not meet your requirements, please contact us for your exclusive solution.

All listed services and products are for research use only. Do not use in any diagnostic or therapeutic applications.

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