γδ T Cell Therapy Development Services

What is γδ T Cell?

As the main component of the immune system, T cells protect the body from infections and tumors by a diversity of bio-functions, including recognition and presentation specific antigens, directly killing target cells, secretion cytokines, assisting or inhibiting antibody production by B cells, etc. These functional T cells are distinguished by a variety of surface receptors, biomarkers, and biological activities.

Fig.1 γδ T cells diagram.

T cell receptor (TCR) on the surface of T cells is a heterodimer composed of four polypeptide chains, α, β, γ, and δ chain. According to the composition of TCR expressed on the surface, T cells are principally divided into αβ T cells, commonly known as T cells expressing αβTCR and accounting for more than 95% of the total number of T cells, and γδT cells, often referred to as expressing γδTCR and accounting for 1%~5% of peripheral blood T cells. γδ T cells perform a broad range of biological effects, although in small amounts, such as:

• Recognizing and binding to antigens directly without the presentation of antigen-presenting cells (APC);
• Functioning as APC and initiate specific immune response;
• Participating in immune regulation through secreting a variety of cytokines and chemokines;
• Significant cytotoxicity to lyse target cells through multiple pathways;
• Activating and promoting the maturation of the dendritic cell.

Fig.2 receptor-ligand recognition and the antitumor response of γδ T cells. (Sengupta, 2019)

γδ T Cell Therapy

The extraordinary properties endow γδ T cells with great potential for disease immunotherapy, including tumors, infections, auto-immune disorders. Firstly and most importantly, γδ T cells can effectively and directly recognize and respond to self-antigens expressed by malignant cells in a major histocompatibility complex (MHC)-unrestricted manner, which has been extensively utilized for the development of tumor therapy. Secondly, by producing a variety of cytokines and chemokines, such as interleukins, interferon-γ (IFN-γ), tumor necrosis factor α (TNF-α), γδ T cells recruit and regulate other immunocytes, and enhance the cell-mediated immune response against infections. Moreover, γδ T cells make a great contribution to the epidermal homeostasis, and promote wound healing by locally secreting epithelial growth factors and inflammatory cytokines.

Since the discovery in 1984, γδ T cell therapy has made great advancements for the tumor and cancer treatment over the past few decades. Currently, γδ T cells and their subsets having been researched and performed for the effective treatment of various diseases by numbers of preclinical and clinical trials, mainly including:

Tumors and cancers Pathogen infections Autoimmune diseases Wounds healing Neurological diseases

Start Your γδ T Cell Therapy Research, Choose Creative Biolabs!

As a leading biotechnology company keeping pace with times, Creative Biolabs has invested numerous energy and efforts in the development of T cell immunotherapy. Based on conventional T cell therapy, we now provide comprehensive “unconventional” γδ T cell therapy development services for global customers.

• Fully customized: all services are based on your specific needs
• One-stop services: widely covering from γδ T cell engineering to therapy development and related applications
• Specially established platform: the combination of advanced biological techniques with a distinguished scientist team provides strong support for our services.
• Industry leadership: our industry-leading expertise in immunotherapy research and drug discovery can help you promote your therapeutic and medical projects.

Please feel free to contact us and our experienced technicians will give you the most detailed answers to your questions.

Reference

1. Sengupta, S. Gamma-delta T cells in glioblastoma immunotherapy. Glioma. 2019, 2(1): 30.