CAR Engineered γδ T Cell Development Services

Chimeric antigen receptor (CAR)-engineered γδ T cell represents a new type of immunotherapy that utilizes T cell immunity against various kinds of tumors. There is increasing evidence to report the exciting results of CAR-modified γδ T cells in the treatment of cancer. γδ T cells, an important population of T cells, have several advantages in fighting tumor cells such as strong cytotoxic effects on tumor cells. They are considered as promising candidates for developing cell immunotherapy. γδ T cells engineered to express a CAR can recognize a certain tumor antigen and activate immune cells against tumor cells, which paves a new way for tumor treatment.

Creative Biolabs has organized a staff of outstanding scientists who have engaged in γδ T cell research and γδ T cell based immunotherapy development for many years. We are committed to providing a full range of CAR engineered γδ T cell development services, including design and generation of CAR, CAR lentivirus production, γδ T cell preparation, transduction of activated γδ T cells with CAR-encoding lentivirus, and validation of CAR γδ T cell. Our one-stop high-quality services will accelerate the development of CAR-γδ T cells for tumor treatment.

CAR Generation for Engineered γδ T Cell

Screening and sequencing of scFvs that are specific to the cancer antigens

Design and construct scFv-CAR of different varieties such as mono-scFv CAR and dual scFv CAR

Validation of specificities and activities for scFv-CAR constructs

Production of high titer lentivirus for scFv-CAR constructs

γδ T-Cell Preparation for CAR Lentivirus Transduction

Isolate, activate and expand primary γδ T cells from healthy donors or patients

Validation of CAR γδ T Cells

Assay of CAR expression

CAR-γδ T cell expansion

Assay of multiplex cytokine production

Cytotoxicity test using co-culture of target cells and CAR-γδ T cells

Testing efficacy, viability, bio-distribution, and toxicity of CAR-γδ T cells using animal model

CAR Transduction for Engineered γδ T Cell

Transduction of activated γδ T cells with CAR-encoding lentivirus

Various transfection technology available

Transfection method tailored for different cell types

Our Advantages

• An excellent expert team support whole-process technical trace and direction
• One-stop services from project design to the best results delivery
• Rich experience for the development of CAR-γδ T cells
• A variety of solutions for developing CAR-γδ T cell
• Advanced analysis platforms to ensure the high-quality CAR-γδ T cell delivery

Our high-quality services will accelerate the process of development of CAR γδ T cells. Contact us for more information about our CAR engineered γδ T cell development services.