γδ T Cells Combined with Immune Checkpoint Inhibitors

Introduction of Immune Checkpoint Inhibitors (ICIs)

By targeting T cell inhibitory molecules and reinvigorating exhausted T cells, ICIs have opened a new chapter in cancer treatment. Types of ICIs currently approved include cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) inhibitors. Creative Biolabs is committed to the research of T cells. We know that blocking immune checkpoint is one of the effective strategies to enhance T cell activation. Therefore, we provide relevant services to customers around the world.

Vγ9Vδ2 T Cells Improve the Potency of Immune Checkpoint (ICP) Blockade

Vγ9Vδ2 T cells have a multi-faceted array of immune functions. They can be regarded as very sensitive biosensors of the immune-suppressive TME commitment occurring in the bone marrow (BM) of Undetermined Significance (MGUS) and Multiple Myeloma (MM) patients. They also act as candidates for immunotherapy. Vγ9Vδ2 T cells isolated from the BM from MM patients are excellent tools to investigate the mechanisms of resistance to PD-1 blockade and to decipher the network of mutual interactions between PD-1 and the immune-suppressive tumor microenvironment. Vγ9Vδ2 T cells have been shown to act as investigational tools to improve the potency of immune checkpoint (ICP) blockade and immune interventions in MM.

γδ T Cell Services

Under normal physiological conditions, immune checkpoints regulate immune response to promote self-tolerance and prevent autoimmunity. Immune checkpoints therapy combined with γδ T cells has been regarded as a promising treatment for different cancers. Our scientists are interested in the study of immune checkpoint inhibitors and γδ T cells. Our aim is to provide the most professional service for global customers about the combination of these two powerful tools.

Immune checkpoints therapy combined with γδ T cells has been regarded as a promising treatment for different cancers. As a leader in the field of immune cell technology, Creative Biolabs provides the most professional technical services in isolation of mononuclear cells, induction and culture of immune cells (such as γδ T cells) in vitro, cell activity analysis and phenotypic analysis. We provide you with the most authoritative service in every aspect of your project. If you have any questions, please contact us.